Retatrutide activates the GIP, GLP-1 and glucagon receptors that are involved with controlling hunger and satiety, allowing people to feel fuller after eating for longer. This helps to regulate blood sugar levels, leading to weight loss
Retatrutide is a single peptide that consists of 39 amino acids engineered from a GIP peptide backbone to stimulate GLP-1, GIP, and GCGRs (Fig. 1). There are three non-coded amino acid residues [two α-amino isobutyric acids (Aib), and one α-methyl-L-leucine (αMeL)] at positions 2, 20, and 13 of the peptide
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